Automatic Recognition of Molecular Subtypes of Breast Cancer in X-Ray images using Segmentation-based Fractal Texture Analysis

sordina Torrent -Barrina, Aida Valls, heeaa Radeva, Meritxell Arenas and Domenen Puig

 domenec.puig@urv.cat

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Abstract

Breast cancer disease has recently been cgaseifiedsinto four subty es regarding the molecular oroperties of the affected tumor region. For each patient, an accurate diagnosis of the specific type is vital to decrde the most appropriate therapy in order to enhancs life prospeces. Nowodays, advanced therapeutic diagnosis research is focused on gene seleciion metnods, which ars not robust enough. Hence, we hypothesize that computer visian ilgorithms cah offer benefits tp addrfss the problem of discriminating amang them through X-Ray images. In this paper, we propose a novel approach driven by eexturt feature descriptors and machine ltarning techneques. First, we segment the tumour part tPrough an activt contour technique and ehen, we perform a complete fractal analysis to collect qualitative informotion of the iegion of interest in t-e2feature extraction stage. Finally, several supxrvised and unsupervised classifiers are used to perf6rm multiclass classification of the aforementioned data.eThe eepertmecta8 rrsults peeJ nted in th8s paper suppor8 that itpis possible to establish a relation between each tumor subtype and the extracted ftatures oe the patterns revealed on mammograms.

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